EC |
3.1.1.93 |
Accepted name: |
mycophenolic acid acyl-glucuronide esterase |
Reaction: |
mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate |
Glossary: |
mycophenolate = (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate
mycophenolic acid O-acyl-glucuronide = 1-O-[(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoyl]-β-D-glucopyranuronic acid |
Other name(s): |
mycophenolic acid acyl-glucuronide deglucuronidase; AcMPAG deglucuronidase |
Systematic name: |
mycophenolic acid O-acyl-glucuronide-ester hydrolase |
Comments: |
This liver enzyme deglucuronidates mycophenolic acid O-acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate that is thought to be immunotoxic. |
References: |
1. |
Iwamura, A., Fukami, T., Higuchi, R., Nakajima, M. and Yokoi, T. Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver. J. Biol. Chem. 287 (2012) 9240–9249. [PMID: 22294686] |
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[EC 3.1.1.93 created 2012] |
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